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            Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

            MLB World Series Futures for 2023: Odds, Predictions, Who Will win – Sports Illustrated

            Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

            Scientists gain insights into Old Master artists' use of egg in oil … – The Guardian

            Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

            Virtual Reality in nursing education goes mainstream – Wolters Kluwer

            Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

            Labour officially bans Jeremy Corbyn from standing as candidate for party at next general election – UK politics live – The Guardian

            Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

            France braces for anti-pension reform protests amid rising violence on the streets – CNN

            Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

            Packers puzzled as talks with QB Rodgers 'never transpired' – ESPN

            Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

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              Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

              North Carolina Expands Medicaid After Republicans Abandon Their Opposition – The New York Times

              Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

              You Were Missed! Just Cooking BBQ And More Is Moving To Killeen … – ktemnews.com

              Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

              Columbia County Health and Wellness Expo – WJBF-TV

              Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

              The Acidic Foods To Avoid Cooking On Top Of Aluminum Foil – Daily Meal

              Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

              5 Ways to Help Protect Your Health During Spring Break … – Times of San Diego

              Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

              20 Ways To Use Textured Vegetable Protein In Your Cooking – Tasting Table

              Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

              Joint statement on regional healthcare facilities' masking … – Tacoma-Pierce County Health Department

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                Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

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                City of Fort Dodge prepares to borrow $14.5 million – Fort Dodge Messenger

                Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

                Jurupa Hills TV production students are honored at SBVC Film Festival – Fontana Herald-News

                Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

                Vote for the first Player of the Week of the spring sports season – Delmarva Now

                Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

                'Succession' Season 4 Release Schedule – When Do New Episodes Drop? – Men's Health

                Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

                Fantasy Baseball Rankings 2023: Breakouts, sleepers, busts by computer model that predicted Votto's struggles – CBS Sports

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                  Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

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                  Toledo Technology students get early look at engineering careers – Toledo Blade

                  Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

                  Technology has become the double-edged sword of Asia's protests – BBC

                  Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

                  Panera Bread will use palm-scanning technology for its loyalty program – WLTX.com

                  Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

                  Hong Kong entering a 'golden era' of I&T, with major career opportunities – South China Morning Post

                  Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

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                  COVID Vaccines From Novavax And Medicago Could Debut Soon : Shots

                  by Editor
                  June 6, 2021
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                  COVID Vaccines From Novavax And Medicago Could Debut Soon : Shots
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                  A vial of the experimental Novavax coronavirus vaccine is ready for use in a London study in 2020. Novavax’s vaccine candidate contains a noninfectious bit of the virus — the spike protein — with a substance called an adjuvant added that helps the body generate a strong immune response.

                  Alastair Grant/AP


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                  Alastair Grant/AP


                  A vial of the experimental Novavax coronavirus vaccine is ready for use in a London study in 2020. Novavax’s vaccine candidate contains a noninfectious bit of the virus — the spike protein — with a substance called an adjuvant added that helps the body generate a strong immune response.

                  Alastair Grant/AP

                  A new kind of COVID-19 vaccine could be available as soon as this summer.

                  It’s what’s known as a protein subunit vaccine. It works somewhat differently from the current crop of vaccines authorized for use in the U.S. but is based on a well-understood technology and doesn’t require special refrigeration.

                  In general, vaccines work by showing people’s immune systems something that looks like the virus but really isn’t. Consider it an advance warning; if the real virus ever turns up, the immune system is ready to try to squelch it.

                  In the case of the coronavirus, that “something” is one of the proteins in the virus — the spike protein.

                  The vaccines made by Johnson & Johnson, Moderna and Pfizer contain genetic instructions for the spike protein, and it’s up to the cells in our bodies to make the protein itself.

                  A Vaccine Patch Could Someday Be An Ouchless Option

                  The first protein subunit COVID-19 vaccine to become available will likely come from the biotech company, Novavax. In contrast to the three vaccines already authorized in the U.S., it contains the spike protein itself — no need to make it, it’s already made — along with an adjuvant that enhances the immune system’s response, to make the vaccine even more protective.

                  Protein subunit vaccines made this way have been around for a while. There are vaccines on the market for hepatitis B and pertussis based on this technology.

                  A large test of the Novavax COVID-19 vaccine’s effectiveness, conducted in tens of thousands of volunteers in the United States and Mexico, is about to wrap up. Dr. Gregory Glenn, president of research and development for Novavax, told an audience at a recent webinar hosted by the International Society for Vaccines that “we anticipate filing for authorization in the U.K., U.S. and Europe in the third quarter.”

                  Turning plants into factories

                  To make the virus protein, Novavax uses giant vats of cells grown in the lab. But there’s another way to make the protein: Get plants in a greenhouse to do it.

                  That’s the approach being used by the Canadian biotech firm Medicago.

                  The plants used are related to the tobacco plant, and have been modified to contain the genetic instructions to make the viral protein.

                  The plants do something very valuable — they make a lipid shell that surrounds a bunch of the viral proteins, with the proteins sticking out.

                  “The plant will assemble the protein in a shape and form that is looking like the virus,” says Nathalie Landry, Medicago’s executive vice president for scientific and medical affairs. “So, if you look at an image of it, it looks like a virus, but it cannot induce any disease. But when [it’s] injected as a vaccine your body will raise a good immune response.”

                  Early studies suggest Medicago’s candidate vaccine does just that, and the company is confident enough in those findings that it’s already begun a large study in people that could involve as many as 30,000 volunteers in 11 countries.

                  Landry acknowledges that development of the Medicago COVID-19 vaccine has lagged behind others.

                  “We’re a latecomer, but we’re coming,” she says.

                  Another latecomer that’s coming is the pharmaceutical giant Sanofi. Its protein subunit vaccine against the coronavirus is also grown in cells in the lab.

                  Late last year the company was getting ready to mount a large study of the vaccine’s effectiveness when the early results in a smaller group of people showed it did not seem to be inducing the immune response that would be protective.

                  “Especially in elderly individuals in that study, it was not as immunogenic as it should be,” says Dr. Paul Goepfert at the University of Alabama at Birmingham, who was one of the researchers involved in those early studies. He says the issue turned out to be an incorrect calculation of the dose of vaccine being delivered.

                  “So instead of giving 10 micrograms of the dose, they were actually giving one microgram,” Goepfert says.

                  Sanofi has fixed that problem and repeated the early studies with good results. The company is now enrolling volunteers in a large efficacy trial.

                  Guns, Trucks And Trips: West Virginia Expands Prizes For Vaccinated Residents

                  Goepfert says it’ll be a good thing if all these vaccines make it to consumers. But that alone isn’t going to solve the problem of getting people vaccinated.

                  Why? “Because the vaccines that we have now are just beyond our wildest dreams kind of effective,” he says. “And I’m living in a state right now where it just frustrates me how slow our vaccine uptake is.”

                  Goepfert lives in Alabama. According to the latest numbers from the Centers for Disease Control and Prevention, only Mississippi has a lower per capita rate of vaccination.



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