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            Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

            Naperville News Digest: Businesses cited for selling tobacco to underage buyers; Edward seeking dogs for therapy … – Chicago Tribune

            Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

            MLB World Series Futures for 2023: Odds, Predictions, Who Will win – Sports Illustrated

            Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

            Scientists gain insights into Old Master artists' use of egg in oil … – The Guardian

            Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

            Virtual Reality in nursing education goes mainstream – Wolters Kluwer

            Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

            Labour officially bans Jeremy Corbyn from standing as candidate for party at next general election – UK politics live – The Guardian

            Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

            France braces for anti-pension reform protests amid rising violence on the streets – CNN

            Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

            Packers puzzled as talks with QB Rodgers 'never transpired' – ESPN

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              Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

              North Carolina Expands Medicaid After Republicans Abandon Their Opposition – The New York Times

              Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

              You Were Missed! Just Cooking BBQ And More Is Moving To Killeen … – ktemnews.com

              Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

              Columbia County Health and Wellness Expo – WJBF-TV

              Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

              The Acidic Foods To Avoid Cooking On Top Of Aluminum Foil – Daily Meal

              Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

              5 Ways to Help Protect Your Health During Spring Break … – Times of San Diego

              Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

              20 Ways To Use Textured Vegetable Protein In Your Cooking – Tasting Table

              Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

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                Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

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                City of Fort Dodge prepares to borrow $14.5 million – Fort Dodge Messenger

                Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

                Jurupa Hills TV production students are honored at SBVC Film Festival – Fontana Herald-News

                Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

                Vote for the first Player of the Week of the spring sports season – Delmarva Now

                Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

                'Succession' Season 4 Release Schedule – When Do New Episodes Drop? – Men's Health

                Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

                Fantasy Baseball Rankings 2023: Breakouts, sleepers, busts by computer model that predicted Votto's struggles – CBS Sports

                Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

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                  Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

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                  Toledo Technology students get early look at engineering careers – Toledo Blade

                  Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

                  Technology has become the double-edged sword of Asia's protests – BBC

                  Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

                  Panera Bread will use palm-scanning technology for its loyalty program – WLTX.com

                  Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

                  Hong Kong entering a 'golden era' of I&T, with major career opportunities – South China Morning Post

                  Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

                  Cowbell opens new technology center in Pune, India – Reinsurance News

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                  Treating neurological symptoms of CHARGE syndrome

                  by Editor
                  April 28, 2021
                  in Science
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                  Treating neurological symptoms of CHARGE syndrome
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                  IMAGE: INRS Professor Kessen Patten specializes in genetics and neurodegenerative diseases.
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                  Credit: Christian Fleury (INRS)

                  CHARGE syndrome is a rare genetic disorder affecting about 1 in 10,000 newborns. It can lead to neurological and behavioural disorders for which no treatment is currently available. Dr. Kessen Patten and his team, from the Institut national de la recherche scientifique (INRS) have just discovered a compound that could alleviate these symptoms. The results of their research were published in the journal EMBO Reports.

                  Understanding Neurological Disorders

                  First described in 1979, CHARGE syndrome is caused by mutations in the CHD7 gene and is associated with neurodevelopmental disorders such as intellectual disability, attention deficit disorder with or without hyperactivity, seizures and autism spectrum disorder. Dr. Patten’s research team studied the neurological symptoms of this syndrome, which are still poorly understood.

                  The team developed a genetic model of zebrafish with loss of function of the CHD7 gene similar to that observed in humans. They found that the CHD7 gene regulated the type of GABAergic neurons that are essential for proper brain function.

                  “The loss of function of CHD7 appears to cause developmental and functional abnormalities in GABAergic neurons in the zebrafish brain that are related to the observed neurological and behavioural disorders,” explained Dr. Patten, who specializes in genetics and neurodegenerative diseases. The team also identified molecular events controlled by the CHD7 gene to explain these neurological symptoms in their genetic model. Similar findings were made using cells from patients with the disease.

                  Finding a Drug

                  The research team tested hundreds of compounds already approved for clinical use by the U.S. Food and Drug Administration. Drug screening was used to identify potential candidates for treatment–ephedrine was selected as the most therapeutic compound. “We observed therapeutic effects on both, the neurological and behavioural symptoms,” said PhD student Priyanka Jamadagni, lead author of the article. “It allowed the diseased zebrafish model to partially recover its normal functions.”

                  This research opens the door to new avenues for the treatment of other neurological disorders with similar neuronal imbalances, such as autism spectrum disorder and hyperactivity.

                  ###

                  About the study

                  The article “Chromatin remodeler CHD7 is required for GABAergic neuron development by promoting PAQR3 expression,” by Priyanka Jamadagni, Maximilian Breuer, Kathrin Schmeisser, Tatiana Cardinal, Betelhem Kassa, J Alex Parker, Nicolas Pilon, Eric Samarut, and Shunmoogum A. Patten, was published in the journal EMBO Reports. Led by Dr. Patten, the study was conducted with the help of collaborators from the CHUM Research Centre and Université de Québec à Montréal (UQAM). The study received financial support from the CHARGE Syndrome Foundation, the Canada Foundation for Innovation (CFI), the Natural Sciences and Engineering Research Council of Canada (NSERC), and the Rare Disease Foundation. The lead author holds a doctoral scholarship from the Center of Excellence in Research on Orphan Diseases – Courtois Foundation (CERMO-FC) and a scholarship from the Armand-Frappier Foundation.

                  About INRS

                  INRS is a university dedicated exclusively to graduate level research and training. Since its creation in 1969, INRS has played an active role in Quebec’s economic, social, and cultural development and is ranked first for research intensity in Quebec and in Canada. INRS is made up of four interdisciplinary research and training centres in Quebec City, Montreal, Laval, and Varennes, with expertise in strategic sectors: Eau Terre Environnement, Énergie Matériaux Télécommunications, Urbanisation Culture Société, and Armand-Frappier Santé Biotechnologie. The INRS community includes more than 1,500 students, postdoctoral fellows, faculty members, and staff.

                  Source :

                  Audrey-Maude Vézina

                  Service des communications de l’INRS

                  418 254-2156

                  audrey-maude.vezina@inrs.ca

                  Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.



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