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    Biden’s Education Secretary Confirmed – The New York Times

    Biden’s Education Secretary Confirmed – The New York Times

    Tao Geoghegan Hart: ‘Everything is political. We are all in this together’ | Cycling

    Three ways to help a friend on World Teen Mental Wellness Day

    Three ways to help a friend on World Teen Mental Wellness Day

    Greene County sheriff confirms bodies found in Benton County, Mo. are missing father, 2 sons

    Greene County sheriff confirms bodies found in Benton County, Mo. are missing father, 2 sons

    Virtual Science Café Las Vegas: Josh Greenwood | Calendar

    Virtual Science Café Las Vegas: Josh Greenwood | Calendar

    Novak Djokovic ties Roger Federer’s record for most weeks as ATP world No. 1

    Novak Djokovic ties Roger Federer’s record for most weeks as ATP world No. 1

    FedEx Hosts 9th Annual Small Business Grant Contest

    FedEx Hosts 9th Annual Small Business Grant Contest

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      Commercial Cooking Equipment Market: Find Out Essential Strategies to expand The Business and Also Check Working in 2021-2029 – KSU

      Commercial Cooking Equipment Market: Find Out Essential Strategies to expand The Business and Also Check Working in 2021-2029 – KSU

      ‘I Think It’s a Mistake’ – NBC Boston

      ‘I Think It’s a Mistake’ – NBC Boston

      Stove becomes stage in Playful People’s interactive cooking class with theater twist

      Stove becomes stage in Playful People’s interactive cooking class with theater twist

      Polk County Health Department Restaurant Scores from the Wednesday, March 3, 2021 edition | Georgia News

      Polk County Health Department Restaurant Scores from the Wednesday, March 3, 2021 edition | Georgia News

      Chili cook-off brings crowds to downtown Kalamazoo on a sunny Saturday

      Chili cook-off brings crowds to downtown Kalamazoo on a sunny Saturday

      Buffalo community holds blood drive in honor of health care workers after fatal clinic shooting

      Buffalo community holds blood drive in honor of health care workers after fatal clinic shooting

      David Moyes cooking up a plan to take on Pep Guardiola’s ‘outrageous’ Manchester City

      David Moyes cooking up a plan to take on Pep Guardiola’s ‘outrageous’ Manchester City

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        AMI sports abound – Anna Maria Island News

        AMI sports abound – Anna Maria Island News

        Review: Elk hunters become the hunted in novel ‘Dark Sky’ | Entertainment

        Review: Elk hunters become the hunted in novel ‘Dark Sky’ | Entertainment

        It’s March, The Month When The Tokyo Olympics Were Postponed

        It’s March, The Month When The Tokyo Olympics Were Postponed

        Irv Cross, broadcasting legend with CBS Sports and Pro Bowl NFL cornerback, dies at 81

        Irv Cross, broadcasting legend with CBS Sports and Pro Bowl NFL cornerback, dies at 81

        Review: Uzbek pianist Bezhod Abduraimov delivers bravura performance Sunday at Lied | Entertainment

        Review: Uzbek pianist Bezhod Abduraimov delivers bravura performance Sunday at Lied | Entertainment

        GIRLS’ PREP BASKETBALL: Central falls just short against Anderson | High School Sports

        GIRLS’ PREP BASKETBALL: Central falls just short against Anderson | High School Sports

        Horoscope: Sunday, Feb. 28 | Entertainment | journalnow.com – Winston-Salem Journal

        Horoscope: Sunday, Feb. 28 | Entertainment | journalnow.com – Winston-Salem Journal

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          PayScale and Payfactors Join Forces to Create Compensation Technology and Data Powerhouse

          PayScale and Payfactors Join Forces to Create Compensation Technology and Data Powerhouse

          Fred Eberle’s diesel technology program tackles rapidly evolving field

          Fred Eberle’s diesel technology program tackles rapidly evolving field

          Online privacy & technology reshaping society – Big Ideas

          Online privacy & technology reshaping society – Big Ideas

          Italian bond yields edge off highs, politics in focus – Yahoo Finance

          Align Technology Inc (ALGN) Files 10-K for the Fiscal Year Ended on December 31, 2020

          Collusion and collisions – The new rules of competition in the technology industry | Business

          Collusion and collisions – The new rules of competition in the technology industry | Business

          Asetek Liquid Cooling Technology is at the Heart of SAPPHIRE’s New TOXIC AMD RADEON™ RX 6900 XT Limited Edition Graphics Card with Hybrid GPU Cooler

          OneConnect Financial Technology and Singapore Exchange collaborate to address the region’s ESG reporting needs

          JPMorgan and Citi are using blockchain technology, and other banks are considering allowing clients to hold crypto in bank accounts, Bank of America research finds | Currency News | Financial and Business News

          JPMorgan and Citi are using blockchain technology, and other banks are considering allowing clients to hold crypto in bank accounts, Bank of America research finds | Currency News | Financial and Business News

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            Biden’s Education Secretary Confirmed – The New York Times

            Biden’s Education Secretary Confirmed – The New York Times

            Tao Geoghegan Hart: ‘Everything is political. We are all in this together’ | Cycling

            Three ways to help a friend on World Teen Mental Wellness Day

            Three ways to help a friend on World Teen Mental Wellness Day

            Greene County sheriff confirms bodies found in Benton County, Mo. are missing father, 2 sons

            Greene County sheriff confirms bodies found in Benton County, Mo. are missing father, 2 sons

            Virtual Science Café Las Vegas: Josh Greenwood | Calendar

            Virtual Science Café Las Vegas: Josh Greenwood | Calendar

            Novak Djokovic ties Roger Federer’s record for most weeks as ATP world No. 1

            Novak Djokovic ties Roger Federer’s record for most weeks as ATP world No. 1

            FedEx Hosts 9th Annual Small Business Grant Contest

            FedEx Hosts 9th Annual Small Business Grant Contest

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              Commercial Cooking Equipment Market: Find Out Essential Strategies to expand The Business and Also Check Working in 2021-2029 – KSU

              Commercial Cooking Equipment Market: Find Out Essential Strategies to expand The Business and Also Check Working in 2021-2029 – KSU

              ‘I Think It’s a Mistake’ – NBC Boston

              ‘I Think It’s a Mistake’ – NBC Boston

              Stove becomes stage in Playful People’s interactive cooking class with theater twist

              Stove becomes stage in Playful People’s interactive cooking class with theater twist

              Polk County Health Department Restaurant Scores from the Wednesday, March 3, 2021 edition | Georgia News

              Polk County Health Department Restaurant Scores from the Wednesday, March 3, 2021 edition | Georgia News

              Chili cook-off brings crowds to downtown Kalamazoo on a sunny Saturday

              Chili cook-off brings crowds to downtown Kalamazoo on a sunny Saturday

              Buffalo community holds blood drive in honor of health care workers after fatal clinic shooting

              Buffalo community holds blood drive in honor of health care workers after fatal clinic shooting

              David Moyes cooking up a plan to take on Pep Guardiola’s ‘outrageous’ Manchester City

              David Moyes cooking up a plan to take on Pep Guardiola’s ‘outrageous’ Manchester City

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                AMI sports abound – Anna Maria Island News

                AMI sports abound – Anna Maria Island News

                Review: Elk hunters become the hunted in novel ‘Dark Sky’ | Entertainment

                Review: Elk hunters become the hunted in novel ‘Dark Sky’ | Entertainment

                It’s March, The Month When The Tokyo Olympics Were Postponed

                It’s March, The Month When The Tokyo Olympics Were Postponed

                Irv Cross, broadcasting legend with CBS Sports and Pro Bowl NFL cornerback, dies at 81

                Irv Cross, broadcasting legend with CBS Sports and Pro Bowl NFL cornerback, dies at 81

                Review: Uzbek pianist Bezhod Abduraimov delivers bravura performance Sunday at Lied | Entertainment

                Review: Uzbek pianist Bezhod Abduraimov delivers bravura performance Sunday at Lied | Entertainment

                GIRLS’ PREP BASKETBALL: Central falls just short against Anderson | High School Sports

                GIRLS’ PREP BASKETBALL: Central falls just short against Anderson | High School Sports

                Horoscope: Sunday, Feb. 28 | Entertainment | journalnow.com – Winston-Salem Journal

                Horoscope: Sunday, Feb. 28 | Entertainment | journalnow.com – Winston-Salem Journal

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                  PayScale and Payfactors Join Forces to Create Compensation Technology and Data Powerhouse

                  PayScale and Payfactors Join Forces to Create Compensation Technology and Data Powerhouse

                  Fred Eberle’s diesel technology program tackles rapidly evolving field

                  Fred Eberle’s diesel technology program tackles rapidly evolving field

                  Online privacy & technology reshaping society – Big Ideas

                  Online privacy & technology reshaping society – Big Ideas

                  Italian bond yields edge off highs, politics in focus – Yahoo Finance

                  Align Technology Inc (ALGN) Files 10-K for the Fiscal Year Ended on December 31, 2020

                  Collusion and collisions – The new rules of competition in the technology industry | Business

                  Collusion and collisions – The new rules of competition in the technology industry | Business

                  Asetek Liquid Cooling Technology is at the Heart of SAPPHIRE’s New TOXIC AMD RADEON™ RX 6900 XT Limited Edition Graphics Card with Hybrid GPU Cooler

                  OneConnect Financial Technology and Singapore Exchange collaborate to address the region’s ESG reporting needs

                  JPMorgan and Citi are using blockchain technology, and other banks are considering allowing clients to hold crypto in bank accounts, Bank of America research finds | Currency News | Financial and Business News

                  JPMorgan and Citi are using blockchain technology, and other banks are considering allowing clients to hold crypto in bank accounts, Bank of America research finds | Currency News | Financial and Business News

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                  Cosmetic laser may boost effectiveness of certain anti-cancer therapies

                  by Editor
                  February 17, 2021
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                  BOSTON – Use of a cosmetic laser invented at Massachusetts General Hospital (MGH) may improve the effectiveness of certain anti-tumor therapies and extend their use to more diverse forms of cancer. The strategy was tested and validated in mice, as described in a study published in Science Translational Medicine.

                  Immune checkpoint inhibitors are important medications that boost the immune system’s response against various cancers, but only certain patients seem to benefit from the drugs. The cancer cells of these patients often have multiple mutations that can be recognized as foreign by the immune system, thereby inducing an inflammatory response.

                  In an attempt to expand the benefits of immune checkpoint inhibitors for additional patients, a team led by David E. Fisher, MD, PhD, director of the Mass General Cancer Center’s Melanoma Program and director of MGH’s Cutaneous Biology Research Center, conducted experiments in mice with a poorly immunogenic melanoma that is not hindered by immune checkpoint inhibitors. The researchers found that exposing the melanoma cells to ultraviolet radiation caused them to take on more mutations, which made immune checkpoint inhibitors more effective at boosting the immune response against the melanomas. Somewhat unexpectedly, the enhanced response included immune attack against non-mutated proteins in the tumor, a process called “epitope spreading.”

                  “Epitope spreading could be important because many human cancers do not have very high mutation numbers, and correspondingly do not respond well to immunotherapy, so a treatment that can safely target nonmutated proteins could be valuable,” Fisher explains.

                  The researchers next sought to find a substitute for the response triggered by mutations after ultraviolet radiation, since it’s likely not safe to add mutations to a patient’s tumor as a treatment strategy. “We discovered that use of a cosmetic laser, also known as a fractional laser, developed at MGH, when shined on a tumor, could trigger a form of local inflammation that mimicked the presence of mutations, strongly enhancing immune attacks against nonmutated tumor proteins, thereby curing many mice of tumors that otherwise did not respond to immunotherapy,” says Fisher.

                  The findings suggest that using such a laser approach, or other methods to optimize immune responses against nonmutated targets on tumors, might make immune checkpoint inhibitors effective against currently incurable cancers.

                  ###

                  This work was supported by the National Institutes of Health; the National Science Foundation; the Cancer Research Institute; the Leukemia and Lymphoma Society; the Dr. Miriam and Sheldon G. Adelson Medical Research Foundation; the Evergrande Center for Immunologic Diseases; Cancer Research UK; the Mildred Scheel Grant of the German Cancer Society; the Filling the Gap Grant of the University of Zurich, Switzerland; and the Swiss National Science Foundation.

                  About the Massachusetts General Hospital

                  Massachusetts General Hospital, founded in 1811, is the original and largest teaching hospital of Harvard Medical School. The Mass General Research Institute conducts the largest hospital-based research program in the nation, with annual research operations of more than $1 billion and comprises more than 9,500 researchers working across more than 30 institutes, centers and departments. In August 2020, Mass General was named #6 in the U.S. News & World Report list of “America’s Best Hospitals.”

                  Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.



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