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            Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

            Heyman: No chink in Act 250’s legislative armor just yet – Vermont Biz

            Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

            World's biggest private security group puts multibillion-dollar IPO on … – Financial Times

            Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

            Ron DeSantis Just Made Life Easier for Parents Who Hate His Book Bans – The Daily Beast

            Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

            Trump indictment: News orgs want indictment unsealed, cameras in court – NBC News

            Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

            No joke winter storm leaves thousands without power, trees downed across Twin Cities – KSTP

            Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

            Texas A&M Physics Festival brings science to life – KBTX

            Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

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              Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

              Plateau Medical Center joining CAMC, Vandalia Health System – WVNS-TV

              Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

              Cooking with Tammy Kelly: Fun Foods for Easter Snacks — Neuse … – Neuse News

              Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

              Cano Health’s Board Drama Comes As Primary Care Firms Try To Attract Buyers – Forbes

              Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

              Food Friday: Italian cooking with James Beard nominated Wisconsin … – Wisconsin Public Radio

              Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

              Bay Cliff Health Camp in need of counselors for summer – WLUC

              Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

              How 100 Top Tables’ Best Chef Silas Li is transforming Chinese cooking – South China Morning Post

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                Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

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                Out & About | Arts & Entertainment | johnsoncitypress.com – Johnson City Press (subscription)

                Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

                Padres Agree to 7-Year Extension with All-Star Infielder – Sports Illustrated

                Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

                Student artists bring life to King Hall stairway – The Bulletin

                Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

                Diamondbacks' uneven Opening Day points to more potential than promise – FOX Sports

                Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

                Fancy food hall, high end shopping coming to Park Square in Uptown – KRQE News 13

                Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

                Kentucky Senate passes bill legalizing sports betting, sends to Beshear – Courier Journal

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                  Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

                  HB Wealth Management LLC Makes New Investment in Micron … – MarketBeat

                  Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

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                  Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

                  Like a Cable Boss: Connecting Medical Technology – DVIDS

                  Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

                  Local Author To Be Published Using State-Of-The-Art Technology – Yellow Scene

                  Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

                  Will Pentagon Rush To Buy Ammo Advance New “Open Energetics Architecture” Technologies? – Forbes

                  Biden State of the Union address likely boosted Democrats' 2024 confidence – NPR

                  Marvell Technology: Upgrade To Buy Post-Haircut (NASDAQ:MRVL) – Seeking Alpha

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                  Cosmetic laser may boost effectiveness of certain anti-cancer therapies

                  by Editor
                  February 17, 2021
                  in Science
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                  Finding coronavirus’s helper proteins | EurekAlert! Science News
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                  BOSTON – Use of a cosmetic laser invented at Massachusetts General Hospital (MGH) may improve the effectiveness of certain anti-tumor therapies and extend their use to more diverse forms of cancer. The strategy was tested and validated in mice, as described in a study published in Science Translational Medicine.

                  Immune checkpoint inhibitors are important medications that boost the immune system’s response against various cancers, but only certain patients seem to benefit from the drugs. The cancer cells of these patients often have multiple mutations that can be recognized as foreign by the immune system, thereby inducing an inflammatory response.

                  In an attempt to expand the benefits of immune checkpoint inhibitors for additional patients, a team led by David E. Fisher, MD, PhD, director of the Mass General Cancer Center’s Melanoma Program and director of MGH’s Cutaneous Biology Research Center, conducted experiments in mice with a poorly immunogenic melanoma that is not hindered by immune checkpoint inhibitors. The researchers found that exposing the melanoma cells to ultraviolet radiation caused them to take on more mutations, which made immune checkpoint inhibitors more effective at boosting the immune response against the melanomas. Somewhat unexpectedly, the enhanced response included immune attack against non-mutated proteins in the tumor, a process called “epitope spreading.”

                  “Epitope spreading could be important because many human cancers do not have very high mutation numbers, and correspondingly do not respond well to immunotherapy, so a treatment that can safely target nonmutated proteins could be valuable,” Fisher explains.

                  The researchers next sought to find a substitute for the response triggered by mutations after ultraviolet radiation, since it’s likely not safe to add mutations to a patient’s tumor as a treatment strategy. “We discovered that use of a cosmetic laser, also known as a fractional laser, developed at MGH, when shined on a tumor, could trigger a form of local inflammation that mimicked the presence of mutations, strongly enhancing immune attacks against nonmutated tumor proteins, thereby curing many mice of tumors that otherwise did not respond to immunotherapy,” says Fisher.

                  The findings suggest that using such a laser approach, or other methods to optimize immune responses against nonmutated targets on tumors, might make immune checkpoint inhibitors effective against currently incurable cancers.

                  ###

                  This work was supported by the National Institutes of Health; the National Science Foundation; the Cancer Research Institute; the Leukemia and Lymphoma Society; the Dr. Miriam and Sheldon G. Adelson Medical Research Foundation; the Evergrande Center for Immunologic Diseases; Cancer Research UK; the Mildred Scheel Grant of the German Cancer Society; the Filling the Gap Grant of the University of Zurich, Switzerland; and the Swiss National Science Foundation.

                  About the Massachusetts General Hospital

                  Massachusetts General Hospital, founded in 1811, is the original and largest teaching hospital of Harvard Medical School. The Mass General Research Institute conducts the largest hospital-based research program in the nation, with annual research operations of more than $1 billion and comprises more than 9,500 researchers working across more than 30 institutes, centers and departments. In August 2020, Mass General was named #6 in the U.S. News & World Report list of “America’s Best Hospitals.”

                  Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.



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